Again, this hypothesis is based upon findings and empirical observations of hundreds of Iridologists. Iridologists have distinguished that the iris changes due to pathological deterioration of body tissue. This shows as a whiteness (acute) in the iris fibers, then an increasing darkness (sub-acute -> chronic -> degenerative) and the depth of iris lesions. In the past, Iridologists have also stated that they have witnessed changes due to reversal pathology (emergence of healing lines.) in the same iris lesions after successful treatment. In many cases these findings are confirmed with other commonly accepted diagnostic procedures.
It must be emphasized that the pathological condition must be adequately severe to be classified by the standards of western medicine as the classification standards of Iridology are different. The various laboratory tests that are being used to determine the presence or absence of disease are not totally efficient in the assessment of sub-clinical conditions. Acute and sub-acute stages of tissue inflammation can commonly be detected long before other diagnostic methods are capable of finding any health problems with the patient. In a similar manner, when a patient is declared “well” by the standards of Western medicine, Iridology frequently shows a sub-acute condition persisting in the individual.
German medical researcher, Walter Lang, has demonstrated that the autonomic nerve fibers from virtually every gland, organ and tissue of the body extend to the thalamus and hypothalamus which monitor and respond to changes of condition in all anatomical structures. These changes of state, Lang suggests, are relayed from the thalamus and hypothalamus through the ophthalmic branch of the trigeminal ganglion to the motorneurons of the iris muscle structure.
Changes in the impulses conducted by these motorneurons may be responsible for the changes in the muscle structure of the iris, leading to the gradual separation of iris fibers in the stroma and consequent appearance of the lesions and other markings familiar to iridologist. Lang also points out that the organization of the human nervous system is genotypic, and further postulates that innervation to the iris reliably represents is also genotypic, which accounts to the fact that the iris reliable represents the same organs, glands, and other anatomical subdivisions of the body in precisely the same locations in the irides of all individuals.